4, 1, 2-benzoxathiazine dioxides and intermediates in their preparation



3,277,087 7 w 4,1,2-BENZXATHIAZINE DIOXIDES AND INTER- MEDIATES IN THEIR PREPARATION Peter H. L. Wei, Upper Darby, and Stanley C. Bell and Scott J. Childress, Philadelphia, Pa., assignors to American Home Products Corporation, New York, N.Y., a

corporation of Delaware No Drawing. Filed Aug. 21, 1964, Ser. No. 391,325 4 Claims. (Cl. 260-243) This invention is concerned with 4,1,2-benzoxathiazine dioxides having a heterocyclic ring fused on the b face thereof, with intermediates in their synthesis and with a process for making such intermediates.

The benzoxathiazine dioxides of this invention have central nervous system activity, antibacterial and antiviral activity as determined by standard test procedures in warm blooded animals. The microorganisms against which particular compounds of the invention were found effective include Bacillus subtilis, Brucella bronchoseptica, Escherichia coli, Lactobacillus casei, Mycobacterium, N eisseria catarrhalis, Pseudomonas aeroginosa, Salm0nella paratyphi, Staphylococcus aureus, and Streptococcus faecalis.

The claimed 4,1,2-benzoxathiazine dioxides arerepresented by the formula:

a )U s wherein X and Y are hydrogen, (lower) alkyl having up to carbon atoms therein, or halogen; Q is a polymethyl ene chain having from 3 to 5 carbon atoms therein; Z.is hydrogen or 2-a1koxy-1-pyrrolidinylsulfonyl, 2-alkoxypiperidin-l-ylsufonyl or Z-alkoxy hexahydroazepin-lsulfonyl.

The claimed o-halosulfonyl phenol intermediates have the general formula:.

X OH

where X and Y are stated and A is hydrogen or chlorosulfonyl.

United States Patent 0 F 3,277,087 Patented Oct. 4, 1966 "ice The claimed o-sul-famyl intermediates have the general formula:

where'inX, Y ad Q are as above stated, B is-hydrogenor SO NHQCH(OR) and R is lower alkyl.

NOMENCLATURE OF FINAL PRODUCTS Depending on whether the heterocyclic ring fused on the benzoxathiazine dioxide nucleus i'sa pyrrole, a pyridine or an azepine ring, the numbering system used in definitively naming the final products of the invention leads to difierent directions of peripheral numbering, as shown below. For the sake of simplicity,.only representative unsubstituted compounds are shown.

1,2,3,10a tetrahydropyrrolo(1,2 b) (4,1,2)benzoxathiazine 5,5-dioxide.

O 1 11% 10a 9! 4 N67 8 g v 8,9,10,1021 tetrahydro 7H pyrid'o(1,2 b) (4,1,2)benzoxathiazine 5,5-dioxide,

7,8,9,19,11,11a hexahydroazepino(1,2 b) (4,1,2)benz0- xathiazine 5,5-dioxide.

PREPARATION OF CLAIMED COMPOUNDS The claimed compounds are prepared by the reactions given below.

In preparing the compounds of the present invention, a

-known 3,4-disu'bstituted phenol (H) is reacted in the coldtreatment with hexane yields the 2,6-disulfonyl chloride 'congener-(III) of the starting material. Thiscompound is treated in an inert solvent with equimolar amounts of an omega-aminoalkyl acetal [H NQCH(OR)2] dissolved in the same solvent. The reaction mixture is .stirred, diluted with water. and extracted with benzene. The benzene solution is dried, the benzene is distilled off The benzene .and theresidue which consists of the crude 2-hydroxy- N,N'-bis(omega,omega'-dialkoxyalkyl) 1,3 'benzenedisulfonamide (IVa) is dissolved in ethanol. The result- -ing alcoholic solution is acidified with hydrochloric acid and allowed to stand overnight. The alcohol is distilled 01f and the residue is dissolved in benzene, the benzene solution is first washed with water and dried. The benzene is removed and the residue is heated on a steam bath while in solution with hexane to give white solids of the two eompoundsshown as Ia and lb. it will be noted from the foregoing flow sheet that because of the presence of two identical cyclizable groups on the nucleus 'of the compounds of Formula IVa, ring formation can take place by the reaction of either of these groups with the hydroxyl group. The unreacted group then undergoes internal ring closure to form the 2-alkoxy-1-heterocyclicsulfonyl substituent.

In another embodiment of the present invention, the substituted phenol starting material (H) is added with cooling to chlorosulfonic acid, and, after stirring, the reaction mixtureis poured on ice. results is extracted with benzene. Then, the benzene extracts are washed with water and dried. Removal of the benzene yields ,the intermediate 2-hydroxybenzenesulfonyl chloride '(V). Compound (V) is dissolved in an The acid solution which i inert solvent such as dimethoxyethane containing an acid scavenger such as triethylamine and reacted with an omega-aminoalkyl acetal of the formula where Q and R are as stated above. This reaction is effected preferably in the cold and with equimolar amounts of the reactants. The resulting reaction mixture is heated, diluted with water and extracted with benzene. The benzene solution is dried, and concentrated. The residue, an N-(omega,omega-dialkoxyalkyl)-2 hydroxybenzenesulfonamide (N12), is dissolved in ethanol. After filtering, the filtrate is acidified, heated and concentrated, and

the residue is dissolved in benzene.- The resulting benzene solution is washed with water, dried and concentrated to give the final product (-10).

The invention is further illustrated by the following examples. It is to be kept in mind that these examples are only given to generally show the processes leading to the new compounds and are not intended to limit the invention.

Example I.'Preparati0n of 5-chloro-4-methyl-2-hydroxy- 1,3-benzenedisulf0nyl chloride To a cold solution of 550 ml. of chlorosulfonic acid was gradually added 200 g. of 4-chloro-3-methylphenol. The solution was heated on a steam bath for two hours and then cooled. Thionyl chloride (200 ml.) wasadded and the mixture heated again for one-half hour. The mixture was slowly poured on cracked ice. I The gummy solid was was treated with hexane to give a crude solid material which was recrystallized from a mixture of benzene and there areobtained, respectively,

5 -bromo-4-methyl-2-hydroxy-1,3,benzenedisulfonyl chloride;

4-chloro-S-methyl-Z-hydroxy-l,3-benzenedisulfonyl chloride;

4-bromo-5-methyl-2-hydroxy-1,3 -'benzenedisulfonyl chloride;

5-butyl-4-chloro-2-hydroxy-1,3-benzenedisulfonyl chloride;

4-butyl-S-chloro-Z-hydroxy-l,3 benzenedisulfonyl chloride.

Example 2. -Preparation of 7-chloro-I,2,3,10a-tetrahydro- 8 and 6 methyl 9 (2-ethoxy-I-pyrrolidinylsulf0nyl) pyrrolo ('1,2-b) (4,1,2) benzoxathiazine 5,5 -di0.xide.

To a cold dioxane solution of'5.0 g. (0.0376 In.) omegaaminobutyraldehyde diethylacetal containing 6.0 g. of

triethylamine was slowly added 9.05 g. (0.0376 m.) of

5 chloro-4-methyl-2-hydroxy-1,3-benzenedisulfonyl chloride in the same solvent. The mixture was stirred for a few minutes, diluted with water and extracted with benzene. The benzene solution was dried over anhydrous magnesium sulfate. After benzene was removed the methoxybutyl)-1,3-benzenedisulfonamide, was dissolved in ethanol and acidified with hydrochloric acid. The solution was let stand at room temperature overnight. Alco- -ho1 was removed and the residue dissolved in benzene. The benzene solution was first washed with water and then dried over anhydrous magnesium sulfate. After removal of benzene the residue was heated with n-hexane to give some white solids. The crude solids were further recrystallized from n-hexane to give the title compound 'rnelting at l38 9 C.

Calcd. for C17H23ClN205S2: C, H, 5.15; Cl,

N, 6.22; S, 14.22. Found: C, 45.56; H, 5.02; CI, 8.14; N, 6.31; S, 14.1.

- When the materials listed under Example I are reacted,

Starting Compounds Intermediates and Final Products 5-bromo-4-methyl-2-hydroxy-L3- benzenedisulionyl chloride and omega-aminobutyraldehyde di- I methyl acetal.

5-bromo-2-hydroxy-4-methyl-N,N'

bis(4,4'd1methoxybutyl)-1,3- benzenedisulfonamide; 7-bromo- 1,2,3,10a-tetrahydro-8- and 6- methyl-9-(2-ethoxy-l-pyrroiidinylsuitonyDpyrrolo (1,2-b)- (4,1,2) benzoxathiazine 5,5- dioxide 5-bromo-4-methyl-2-hydroxy-1,3-

benzenedisulfonyl chloride and omegaaaminovaleraldehyde dimethyl acetal.

bls(5,5-dimethoxypentyl)-1,3- benzenedisulionamide; 3-bromo- 2- and 4-methyl-1-(2-ethoxy-1- piperldinylsulfonyl)-8,9,10,10atetrahydro-7H-gyrido(1,2b)- (4:,1, 2)benzoxat iazine 5,5- zsin dr n romoy oxy-4-met yl-N N'- bls(6,6-dimeth0xyhexyl)-1,3- benzenedisulionamide; 3-bromo- 2- and 4-methyl-1-(2-methoxy-1- hexahydroazepinylsulfonyD- 7,8,9 10,11,11a-hexahydroazepino- (1,2- )(4,1,2) benzoxathiazine 5,5-dioxide. Y

5-bromo-4-methyl-2-hydroxy-1,3-

benzenedisulionyl chloride and omega-aminocaproaldehyde dtmethyl acetal.

Starting Compounds Intermediates and Final Products 2-hydroxy-4-methy1-1,3benzenedisulionyl chloride and omegaaminobutyraldehyde dimethyl acetal.

I 2-hydroxy-4-methy1-1,3-henzenedisulfonyl chloride and omegaamirgpvaleraldehyde dimethyl ace 2-hydroxy-4-methyl-1,3-benzenedisulfonyl chloride and omegaaminocaproaldehyde dimethyl acetal.

5-hutyl-4chloro-2-hydroxy-L3- benzenedisulionyl chloride and omega-aminobutyraldehyde dimethyl acetal.

5-butyl-4-chloro-2-hydroxy-L3- benzenedisulionyl chloride and omega-aminovaleraldehyde dimethyl acetal.

5-buty1-4-chloro-2-hydroxy-L3- benzenedisulionyl chloride and omega-aminocaproaldehyde dimethyl acetal.

hexahydroazepinylsulionyD- 7,8,9,10,11,1la-hexahydroazep1no- (1,2-b) (4,1,2)benzoxath1azine 5,5-dioxide.

Example 3.Preparation of 5-chlor0-2-hydr0xyp-toluene-sulfonyl chloride To 380 ml. of chlorosulfonic acid (cooled in a salt-ice bath) was slowly added 130 g. of 4-chloro-3-methylphenol. The mixture was stirred in an ice bath for min. and then poured into cracked ice. The resulting acid solution was extracted with benzene. Next, the benzene solution was washed with water and dried over anhydrous magnesium sulfate. Following the removal of benezene, the residue was recrystallized from n-hexane.

In similar fashion but using instead of 4-chloro-3 -methylphenol, 4-bromo-3-methylphenol, 3-chloro-4-methylphenol, 3-bromo-4methylphenol, 4-butyl-3-chlorophenyl, and 3-butyl-4-chlorophenol;

there are obtained, respectively:

5-bromo-2-hydroxy-p'toluenesulfonyl chloride, 4-chloro-6-hydroxy-m-toluenesulfonyl chloride, 4-bromo-6-hydroxy-m-toluenesulfonyl chloride, 5 butyl-4-chloro-2-hydroxybenzenesulfonyl chloride, and 4-butyl-5-chloro-2-hydroxybenzenesulfonyl chloride.

Example 4 .Preparatz'on of 7-chl0ro-1,2,3,10a-tetrahydro- 8 methylpyrrolofl ,2 b) (4,1 ,2)benzoxathiazine 5,5- dioxide To a cold dimethoxyethane solution of 3.34 g. (0.0208 In.) of omega-aminobutyraldehyde diethylacetal containing 2.5 g. of triethylamine was slowly added 5.0 g. (0.0208 In.) of S-chl0r0-2-hydr0xy-p-t0luenesulfonyl chloride in the same solvent. The mixture was heated in a water bath, diluted with water and extracted with benzene. The benzene solution, after drying over anhydrous magnesium sulfate, was concentrated and the residue (crude 5-chloro- 2-hydroxy-N-(4,4-diethoxybutyl) -p toluenesulfonamide) was dissolved in ethanol. Some insoluble material was filtered off. The filtrate was acidified with hydrochloric 6 acid, heated on a-steam bath for 15 min. and then concentrated. The residue upon removal of benzene was dissolved in benzene. The resulting benzene solution was washed with water, dried over anhydrous magnesium sulfate and concentrated. The residue was recrystallized from cyclohex-ane, to give the title compound melting at -7 C. Calcd. for C H ClNO S: C, 48.2; H, 4.42; CI, 12; N, 5.11; S, 11.72. Found: C, 48.45; H, 4.57; CI, 12.94; N, 4.87; S, 11.4. V

When the materials listed under Example 3 are reacted with the acetals named below, as described in Example 4, the'corresponding intermediates and final products hereinafter enumerated are obtained.

Starting Compounds Intermediates and Final Products 5-butyl-4-chloro-2-hydroxybenzene- 5-butyl-2-hyrdoxy-4-chloro-N- sulfonyl chloride and omega- (4,4dimethoxybutyl)benzeneaminobutyraldehyde dimethyl sulfonamide; 7-butyl-1,2,3,10aacetal. tetrahydroQ-chloro-pyrrolo (1,2-b) (4,1,2)benzoxathiazine 5,5dioxidc.

5-butyl-4-chloro-2-hydroxybenzene- 5-butyl-4-chloro-2-hydroxy-N- sulfonyl chloride and omega- (5,5-dimethoxypentyD-L3- aminovalemldehyde dimethyl benzenesnlionamide; 3-butyl-2- acetal. chl0r0-8,9,10,10a-tetrahydro- 7H-pyrido(1,2-b) (4,1,2) benzoxathiazine 5,5-dioxide. 5-butyl-4-chloroZ-hydroxybenzene- 5-butyl-4-ohl0ro2-hydroxy-N- sulfonyl chloride and omegaaminocaproaldchyde dimethyl acetal.

2-hydroxy-p-tolnenesulfonyl chloride and omega-aminobutyraldehyde dimethyl acetal.

2-hydroxy-p-t01uenesulfonyl chloride and omega-aminocaproaldehyde dimethyl acetal.

5-bromo-Z-hydroxy-p-toluenesulfonyl chloride and omegaaminobutyraldehyde diethyl acetal.

5-bromo-2-hydroxy-p-toluenesulfonyl chloride and omega-aminovaleraldehyde diethyl acetal.

fi-bromo-Zhydroxy-otoluenesulionyl chloride and omega-aminocaproaldehyde diethyl acetal.

(6,6-dimethoxyhexyl)benzenesulionamide; 3-butyl-4-chloro-7, 8,9,10,11,11a-hexahydroazepino (1,2-b) (4,1,2)benzoxathiazlne 5,5dioxide. 2-hydroxy-4-methyl-N-(4,4-dlmethoxybutyl)benzenesulf0namide; 8-methy1-1,2,3,10a-tetrahydropyrrolo (1,2-b) (4,1,2)benzoxathiazine 5,5-dioxide. 2-hydroxy-4-methyl-N-(6,6-d1- methoxyhexyl(bcnzenesulxonamide; 2-methyl-7,8,9,10,11,11ahexahydroazepino(1,2-b) (4,1,2)- benzoxathlazine 5,5-dioxlde. 5-brorno-2-hydroxy-N-(44diethoxybutyl)-p-toluenesulfonamide; 7-brorno-8-1ncthyl-1,2,3, 10a-tetrahydropyrrolo(1,2-b) (4,1,?)benzoxathiazlne 5,5-

dioxide. 5-bromo-2-hydroxy-N-(5,5-dlethoxypentyl)-p-toluenesulionamide; 3-bromo2-rnethyl- 8,9,10,10a-tetra-7H-hydropyrido(1,2-b) (4,1,2)benzoxathiazine 5,5-dioxide. 5-bromo-2-hydroxy-N-(6,6-diethoxyhexyl) -p-toluenesulfonamide; 3-bromo-2-methyl-7,8,

9,10,11,11a-hexahydr0azeplno (1,2-b) (4,1,2)benzoxathiaz1ne 5,5-dioxide.

The effective dosage of the present compounds can vary over a wide range from about 50 to about 500 milligrams per day or more, administered in the form of tablets, pills, capsules or of injectable solutions with the proper solid or liquid carrier. As the present compounds can be conventionally placed in suitable dosage forms by pharmacists only one example is given below of the various possible unit dosage forms.

Example 4.-Tablet Mg. 7-chloro-1,2,3-10a-tetrahydro-S-methylpyrrolo [1,2-

b] [4,1,2] benzoxathiazine 5,5-dioxide 50 Lactose 26.2 Starch 20.6 Magnesium stearate 0.5

7 What iscl aimed is: 1. A compound of the formula:

wherein X and Y are selected from the group of hydro- ,gen (1ower)alky1 having npfro 5 carbon atoms in the alkyl chain, and halogen; Q is a. polymethylene chain having from 3 to 5 carbon atoms therein; Z is selected hydroazepin-l-yl-sulfonyl.

2. 7 chloro 1,2,3,10a-tetrahydro-8-methyl-9-(Z-ethf oxy 1 pyrrolidinylsulfony)pyrrolo(1,2-b) (4,1,2)benzoxathiazine 5,5-dioxide. 3. 7 chloro 1,2,3-10a tetrahydro-6-methy1-9-(2- ethoxy 1 pyrrolidinylsulfonyl)pyrrolo(1,2-b) (4,1,2) benzoxathiazine 5,5-dioxide.

4. 7 chloro 1,2,3-10a-tetrahydro-S-methyl-pyrrolo (1,2-b) (4,1,2)benzoxathiazine 5,5-dioxide.

No references cited.

WALTER A. MODANCE, Primary Examiner.

from the group of hydrogen, 2-alkoxy-pyrrolidin-l-yl-sul- 15 FORD, Assistant Examiner 

1. A COMPOUND OF THE FORMULA: 